Angiotensin II-stimulated collagen gel contraction by heart fibroblasts: Role of the AT1 receptor and tyrosine kinase activity

1998 ◽  
Vol 177 (2) ◽  
pp. 224-231 ◽  
Author(s):  
Simon Watson ◽  
Taj Burnside ◽  
Wayne Carver
Keyword(s):  
Angiotensin Ii ◽  
Tyrosine Kinase ◽  
Kinase Activity ◽  
Collagen Gel ◽  
At1 Receptor ◽  
Tyrosine Kinase Activity ◽  
Collagen Gel Contraction

The Role of Anaplastic Lymphoma Kinase in Human Cancers

2013 ◽  
Vol 09 (02) ◽  
pp. 149 ◽  
Author(s):  
Alejandro García-Regalado ◽  
Claudia Haydée González-De la Rosa ◽  
◽  
Keyword(s):  
Tyrosine Kinase ◽  
Anaplastic Lymphoma Kinase ◽  
Kinase Activity ◽  
New Drugs ◽  
Tyrosine Kinase Activity ◽  
Mutant Proteins ◽  
Anaplastic Lymphoma ◽  
Attractive Therapeutic Target ◽  
Pathway Inhibition

The anaplastic lymphoma kinase (ALK) is a receptor with tyrosine kinase activity, which regulates the development and maintenance of the nervous system. Mutations or amplification in ALK promote tumorogenesis and progression of diverse types of cancer, which makes it an attractive therapeutic target against cancer diseases. Inhibition of its tyrosine kinase activity with small molecules, such as crizotinib, reveals tumor reversion; however, secondary mutations and amplification of the gene mediate resistance to treatment. In this article, we discuss the emerging role of possible therapeutic targets that could overcome the resistance to ALK inhibition in cancer, such as inhibition of other kinases involved in the pathway, inhibition of ALK mutant proteins through the development of new drugs based on its crystallography, and the use of antibodies against ALK.

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